Killing The Big Flu

Capturing SARS Severe acute respiratory syndrome is a virus which advanced from coronavirus. Its symptoms are similar to those of flu, such as fever, myalgia and a sore throat. An efficient treatment plan remains unsolved however a vaccine has been synthesised. From its birth in Hong Kong, the virus spread throughout thirty-seven countries, killing seven hundred seventy five people and jeopardising the lives of eight thousand more.

Coronavirus is a strain of virus specific to the coronaviridae family; and subfamily corronavirinae. Its infection cycle begins through perpetual replication in the cytoplasm within a protected membrane environment. Post translation, replicase is activated to monocistronically (coding only one gene) reproduce the virus. In adults Coronavirus is a significant cause of flu related symptoms; infections pertaining to the respiratory system and gastrointestinal tract.

Signs of SARS are manifested within ten days of contraction. A fever beyond 38o centigrade after intercourse, or travel in a SARS recognised country, is cause enough for a SARS tests. A lung x-ray of a SARS candidate would illustrate a modified version pneumonia. After which, further testing for coronavirus confirms SARS . Furthermore, SARS patients tend to reflect lower levels of platelets and white blood cells, which serves as a more conclusive test for the condition.

  1. Enzyme Linked immunosorbent assay  – Testing for antibodies pertaining to the SARS virus                             Drawback: Detects SARS 21 Days after infection
  2. Immunoflorecence Assay- Testing for antibodies pertaining to SARS virus with 10 days of infection      Drawback: Detects SARS only ten days after infection however it is expensive and can only be achieved by a trained specialist
  3. Polymerase Chain Reaction: Detection of genetic material pertaining to SARS                                                           Drawback: Even though a poitive test indicates infection, a negitive does not pro e a patient doesnt have SARS

American scientist soon after the outburst of SARS, generated a vaccine which drives the immune system to combat the protein accountable for transmission of the virus. This was achieved by extrapolating the protein accountable for penetrating and contaminating healthy cells. To extract this protein, primers were utilised to replicate the DNA using a polymerase chain reaction. SARS vaccine is a safer alternative to other vaccines because it uses DNA rather than killed forms of the virus itself. This vaccine permits the body to stimulate the production of SARS antibodies in case of a future infection.

In conclusion, SARS causes of flu related symptoms such as respiratory and gastrointestinal infections. Symptoms of SARS are displayed within ten days of contraction and can be confirmed via tests for Coronavirus. There are three tests for SARS however all have unique drawbacks. A SARS vaccine has been partially introduced however further tests are compulsory for it to be valid on a global market. Research in SARS treatment enables the world to be prepared for a future outburst.

References

  1. McBride, R, & Fielding, B 2012, ‘The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis’, Viruses (1999-4915), 4, 11, pp. 2902-2923, Academic Search Complete, EBSCOhost, viewed 28 April 2013.
  2. Cameron, M, Kelvin, A, Leon, A, Cameron, C, Ran, L, Luoling, X, Yong-Kyu, C, Danesh, A, Yuan, F, Qianjun, L, Anderson, A, Couch, R, Paquette, S, Fomukong, N, Kistner, O, Lauchart, M, Rowe, T, Harrod, K, Jonsson, C, & Kelvin, D 2012, ‘Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model’, Plos ONE, 7, 9, pp. 1-16, Academic Search Complete, EBSCOhost, viewed 28 April 2013.
  3. van den Worm, S, Eriksson, K, Zevenhoven, J, Weber, F, Züst, R, Kuri, T, Dijkman, R, Chang, G, Siddell, S, Snijder, E, Thiel, V, & Davidson, A 2012, ‘Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination’, Plos ONE, 7, 3, pp. 1-11, Academic Search Complete, EBSCOhost, viewed 28 April 2013.
  4. Chien-Te, T, Sbrana, E, Iwata-Yoshikawa, N, Newman, P, Garron, T, Atmar, R, Peters, C, & Couch, R 2012, ‘Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus’, Plos ONE, 7, 4, pp. 1-13, Academic Search Complete, EBSCOhost, viewed 28 April 2013.
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